The aryl hydrocarbon receptor (AhR) is a transcription factor that plays a crucial role in the regulation of various biological processes, including metabolism, inflammation, and immune response. AhR is activated by a variety of ligands, including environmental pollutants such as dioxins, as well as dietary compounds such as indoles and flavonoids. Research on the aryl hydrocarbon receptor focuses on understanding its role in health and disease, including its involvement in cancer, autoimmune diseases, and metabolic disorders. Additionally, studies aim to uncover the molecular mechanisms by which AhR signaling impacts various biological pathways and to develop new therapeutic strategies targeting AhR for the treatment of various diseases.